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目的 研究表皮生长因子受体 (EGFR)及转化因子 (TGF α)与胃肠道间质瘤 (GIST)的发生发展关系。方法 采用免疫组织化学方法观察 3 1例GIST(其中 9例恶性间质瘤 ,8例良性间质瘤 ,14例潜在恶性间质瘤 )的EGFR、TGF α的表达情况。结果 EGFR在恶性间质瘤、潜在恶性间质瘤、良性间质瘤 3组中的免疫组织化学方法检出率分别为 88.89%、64 .2 8%、3 7.5 0 % ,后两组与恶性间质瘤组相比差异有显著性 (P <0 .0 5 )。 80 .65 %胃肠道间质瘤表达TGF α ,良性、潜在恶性、恶性的TGF α表达差异无显著性 (P >0 .0 5 )。所有EGFR阳性的GIST均TGF α表达阳性。结论 EGFR在恶性间质瘤中有较高水平的表达 ,在潜在恶性间质瘤中亦呈较高表达 ,表明EGFR在恶性GIST的发生发展中起着重要的作用。GIST存在生长因子自泌循环 ,可能是癌细胞失控生长的主要原因之一
Objective To study the relationship between epidermal growth factor receptor (EGFR) and transforming growth factor (TGF) and gastrointestinal stromal tumors (GIST). Methods Immunohistochemistry was used to detect the expression of EGFR and TGF-α in 31 GIST patients (including 9 malignant stromal tumors, 8 benign stromal tumors and 14 potential malignant stromal tumors). Results The immunohistochemical detection rates of EGFR in malignant stromal tumor, potential malignant stromal tumor and benign stromal tumor were 88.89%, 64.28% and 7.55% respectively, and the positive rates of malignant The difference between the stromal tumor group was significant (P <0.05). There was no significant difference in the expression of TGFα between 80.65% gastrointestinal stromal tumors, benign, potentially malignant and malignant tumors (P> 0.05). All EGFR-positive GISTs are positive for TGFα expression. Conclusion EGFR is highly expressed in malignant stromal tumors and highly expressed in potentially malignant stromal tumors, indicating that EGFR plays an important role in the development of malignant GIST. GIST existence of growth factors autocrine cycle may be one of the main reasons for the uncontrolled growth of cancer cells