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目的探讨年龄对乙型肝炎病毒相关肝癌合并糖尿病患者根治性切除预后的影响。方法回顾性分析250例行肝癌根治性切除的乙型肝炎病毒相关肝癌合并糖尿病患者的临床资料。患者年龄30~80岁,其中≥60岁(老年组)58例,<60岁(非老年组)192例。利用倾向值匹配(propensity score matching,PSM)的方法均衡组间协变量后,比较两组患者的总体生存率,并用Cox回归分析影响肝癌预后的风险因素。结果经PSM法匹配后,老年组(53例)与非老年组(85例)患者的1、3、5年的总体生存率分别为94.5%和90.6%、73.2%和61.2%、52.9%和43.7%,组间差异无统计学意义(P=0.15)。Cox回归多因素分析显示年龄不是影响乙型肝炎病毒相关肝癌合并糖尿病患者预后的独立危险因素。结论高龄并未降低乙型肝炎病毒相关肝癌合并糖尿病患者的术后累积生存率,老年患者可获得与年轻患者类似的生存率。
Objective To investigate the effect of age on prognosis of radical resection in patients with hepatocellular carcinoma associated with hepatitis B virus infection. Methods The clinical data of 250 patients with hepatocellular carcinoma who underwent radical resection of hepatocellular carcinoma associated with hepatocellular carcinoma were retrospectively analyzed. Patients aged 30 to 80 years, of which ≥ 60 years old (elderly group) 58 cases, <60 years old (non-elderly group) 192 cases. After the covariates were balanced by propensity score matching (PSM), the overall survival rate was compared between the two groups. Cox regression was used to analyze the risk factors that affected the prognosis of HCC. Results The overall survival rates at 1, 3 and 5 years in the elderly group (53 cases) and the non-elderly group (85 cases) were 94.5% and 90.6%, 73.2% and 61.2%, 52.9% and 43.7%, no significant difference between groups (P = 0.15). Cox regression multivariate analysis showed that age was not an independent risk factor for the prognosis of patients with hepatocellular carcinoma associated with Hepatitis B virus associated with Hepatitis B virus. Conclusion Older age did not reduce the postoperative cumulative survival rate of patients with hepatocellular carcinoma associated with hepatitis B and elderly patients with similar survival rates.