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目的研究新生儿颅内出血中血浆和脑脊液白介素-6(IL-6)的水平变化与临床意义。方法采用ELISA法测定了新生儿血浆、脑脊液IL-6的含量(新生儿颅内出血22例为实验组,无窒息史、严重感染及神经系统疾病的入院新生儿13例为对照组)。结果实验组血浆、脑脊液中IL-6含量均显著高于对照组(P<0.01,P<0.001),以脑脊液升高更为显著;大出血组其IL-6含量较小出血组均显著升高(P值均为P<0.05);颅高压组其IL-6含量较正常颅压组均显著升高(P<0.05,P<0.01),以脑脊液升高明显。结论新生儿颅内出血患儿血浆和脑脊液中IL-6水平变化与脑损伤严重程度有关,是病情监测和判断预后的指标之一。
Objective To study the changes and clinical significance of interleukin-6 (IL-6) in plasma and cerebrospinal fluid in neonatal intracranial hemorrhage. Methods The content of IL-6 in plasma and cerebrospinal fluid (neonatal intracranial hemorrhage in 22 cases as experimental group, no asphyxia history, serious infection and nervous system diseases) were measured by ELISA in 13 neonates. Results The levels of IL-6 in plasma and cerebrospinal fluid of the experimental group were significantly higher than those of the control group (P <0.01, P <0.001), and were significantly higher in the cerebrospinal fluid (CSF). The levels of IL-6 in the hemorrhage group were significantly higher than those in the control group (P <0.05). The contents of IL-6 in patients with intracranial hypertension were significantly higher than those in patients with normal intracranial pressure (P <0.05, P <0.01). Conclusion The level of IL-6 in plasma and cerebrospinal fluid of neonates with intracranial hemorrhage is related to the severity of brain injury and is one of the indicators of disease monitoring and prognosis.