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作者自小鼠唾液腺中提纯到一种新的生长因子,这种新的生长因子是一种嗜神经的蛋白质,分子量为56 000道尔顿。令人惊奇的是,分裂原刺激的T淋巴细胞也能产生这种因子,故命名为神经白细胞素(Neurole-ukin)。神经白细胞素加入胚胎脊索神经元培养中,能刺激某些神经元亚群的生长,主要是促进骨髓肌运动神经元的生长,也可支持那些对神经生长因子(NGF)不敏感的感觉神经元的生长,但对交感及副交感神经元无作用。
The authors purified from mouse salivary glands to a new growth factor, a neurotropic protein with a molecular weight of 56,000 daltons. Surprisingly, the division of the original stimulated T lymphocytes can also produce this factor, so named for neuronal leukotoxin (Neurole-ukin). Neuroblastoma cells, when added to embryonic rat spinal cord neurons, stimulate the growth of certain neuronal subpopulations primarily to promote the growth of myeloid motor neurons and also to sensory neurons that are insensitive to nerve growth factor (NGF) Growth, but no effect on sympathetic and parasympathetic neurons.