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目的 观察和探讨中国人血清对氧磷酶 1(PON 1)活性与冠状动脉粥样硬化性心脏病的关系。方法 分光光度法测定入选研究对象 (包括 6 1例非冠心病患者 ,15 1例冠心病患者 )的血清PON 1活性 ;以冠状动脉造影结果作为分组依据 ,并分析PON 1活性与冠状动脉病变支数的关系。结果 冠心病组血清PON 1活性明显低于对照组 (t=17.2 5 ,P <0 .0 0 0 1) ;血清PON 1活性单支病变组明显高于双支、三支病变组 (F =9.5 36 ,P <0 .0 5 ) ;而双支和三支病变组比较差异无统计学意义 (P =0 .13)。结论 冠心病患者血清PON 1活性水平明显降低 ,随着病变支数增加 ,血清PON 1活性水平有逐步降低趋势。
Objective To observe and explore the relationship between Chinese plasma PON 1 activity and coronary atherosclerotic heart disease. Methods The serum PON 1 activity of selected study subjects (including 61 non-CHD patients and 15 1 CHD patients) was determined by spectrophotometry. The results of coronary angiography were used as the basis of grouping, and the relationship between PON 1 activity and coronary artery lesion Number of relations. Results Serum PON 1 activity in CHD group was significantly lower than that in control group (t = 17.2 5, P <0.01 01). Serum PON 1 activity in single vessel disease group was significantly higher than that in double vessel and triple vessel disease group (F = 9.5 36, P <0.05). However, there was no significant difference between the two groups and three groups (P = 0.13). Conclusion Serum levels of PON 1 are significantly decreased in patients with coronary heart disease. As the number of lesions increases, serum PON 1 activity gradually decreases.