论文部分内容阅读
目的探讨前列地尔治疗糖尿病足的方法和临床疗效。方法选取2009年1月至2010年12月收治的64例糖尿病足患者。将患者随机分为治疗组和对照组各32例,对照组给予糖尿病饮食、胰岛素治疗并控制血糖在理想范围(7～10mmol/L)内,给予积极抗感染等基本治疗;治疗组在对照组治疗的基础上,加用前列地尔10～20μg加入0.9%氯化钠液100ml静脉滴注,每日1次。连续治疗观察4周后,比较2组的疗效。结果治疗组有效29例,无效3例,有效率为90.6%;对照组有效8例,无效24例,有效率为25.0%。2组有效率比较差异有统计学意义(χ2=28.25,P<0.01)。结论在糖尿病饮食、胰岛素治疗并控制血糖、抗感染及清创处理等治疗的基础上,加用前列地尔静脉滴注治疗糖尿病足,可显著提高治疗效果。
Objective To investigate the method and clinical efficacy of alprostadil in the treatment of diabetic foot. Methods Sixty-four patients with diabetic foot admitted from January 2009 to December 2010 were selected. The patients were randomly divided into treatment group and control group, 32 cases in each group. The control group was given diabetes diet, insulin treatment and blood glucose control in the ideal range (7 ~ 10mmol / L), given positive anti-infection and other basic treatment; On the basis of treatment, plus alprostadil 10 ~ 20μg added 0.9% sodium chloride solution 100ml intravenous infusion, once daily. After 4 weeks of continuous treatment, the efficacy of the two groups was compared. Results In the treatment group, 29 cases were effective and 3 cases were ineffective. The effective rate was 90.6%. In the control group, 8 cases were effective and 24 cases were ineffective. The effective rate was 25.0%. There was significant difference between the two groups (χ2 = 28.25, P <0.01). Conclusion On the basis of diabetes diet, insulin therapy and blood sugar control, anti-infective and debridement treatment, the application of alprostinil for the treatment of diabetic foot can significantly improve the therapeutic effect.