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目的研究超敏C反应蛋白(hsCRP)预测和监视糖尿病并发冠心病的临床价值。方法收集65例糖尿病患者和35例体检正常者的血清,采用免疫透射比浊法检测hsCRP,酶法检测总胆固醇(TC)和高密度脂蛋白胆固醇(HDLC)。结果hsCRP水平正常对照组为(072±067)mg/L,TC正常糖尿病组为(194±136)mg/L,高TC糖尿病组为(374±154)mg/L。TC正常糖尿病组和高TC糖尿病组hsCRP明显高于正常对照组(分别为P<005,P<001);TC正常糖尿病组和高TC糖尿病组之间hsCRP水平差异也有非常显著意义(P<001);同时hsCRP水平与TC水平呈正相关(r=046,P<001),与HDLC水平无相关性。结论hsCRP作为炎症因子,在预测和监视糖尿病患者并发冠心病方面有重要临床意义,是一个强有力的独立筛选指标。
Objective To investigate the clinical value of hsCRP in predicting and monitoring diabetes mellitus complicated with coronary heart disease. Methods The serum of 65 diabetics and 35 normal controls were collected. The hsCRP was detected by immunoturbidimetry and the levels of total cholesterol (TC) and high density lipoprotein cholesterol (HDLC) were measured by enzymatic method. Results The hsCRP level was (072 ± 067) mg / L in normal control group, (194 ± 136) mg / L in TC normal diabetes group and (374 ± 154) mg / L in high TC diabetic group. The hsCRP levels in normal and high-TC group were significantly higher than those in normal control group (P <0.001 and P <0.01, respectively). There was also a significant difference in hsCRP levels between TC normal group and high TC group (P <0.001) ). Meanwhile, there was a positive correlation between hsCRP level and TC level (r = 046, P <001), but not with HDLC level. Conclusion hsCRP as an inflammatory cytokine has important clinical significance in predicting and monitoring coronary heart disease in diabetic patients. It is a powerful independent screening index.