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目的：为探讨急性重复缺氧对机体内血红蛋白（Ｈｂ）和超氧化物歧化酶（ＳＯＤ）含量的变化。方法：在同一人群中选择某部担负喀喇昆仑山运输任务的驾驶员２４ 人，在高原完成全年运输任务的前、中、后进行Ｈｂ、血清总（Ｔ－ ＳＯＤ）、铜锌（ＣｕＺｎ－ ＳＯＤ）、红细胞（ＲＢＣ－ ＳＯＤ）和尿液（Ｕ－ ＳＯＤ）含量的检测。结果：运输中较运输前Ｈｂ 增加非常显著（Ｐ＜ ０．０１），ＲＢ－ ＳＯＤ、ＣｕＺｎ－ ＳＯＤ和Ｔ－ ＳＯＤ、Ｕ－ ＳＯＤ的活性降低差异显著和非常显著（Ｐ＜ ０．０５和Ｐ＜ ０．０１）。运输结束后较运输中Ｈｂ 降低均差异显著（Ｐ＜ ０．０１），Ｔ－ＳＯＤ、Ｕ－ ＳＯＤ和ＲＢＣ－ ＳＯＤ的活性逐渐降低有非显著和显著差异（Ｐ＜ ０．０１ 或Ｐ＜０．０５）。运输结束后较运输前的ＲＢＣ－ ＳＯＤ、Ｔ－ ＳＯＤ、ＣｕＺｎ－ ＳＯＤ、Ｕ－ ＳＯＤ活性降低相差非常显著（Ｐ＜ ０．０１），而Ｈｂ 无显著性差异（Ｐ＞ ０．０５）。结论：急性重复缺氧是影响体内Ｈｂ 和ＳＯＤ含量的变化及造成自由基对机体损伤的主要原因。
Objective: To investigate the changes of hemoglobin (Hb) and superoxide dismutase (SOD) in acute hypoxia. Methods: Twenty-four drivers were selected from the same population who were responsible for the transport of Karakoram Mountain. Hb, total serum T-SOD, CuZn - SOD, RBC-SOD and urine U-SOD were detected. Results: Compared with pre-transport Hb transport, the increase of Hb in transport was significant (P <0.01). The decrease of activity of RB-SOD, CuZn-SOD and T- SOD and U- SOD was significant and significant (P <0.05 and P <0.01). There were significant differences (P <0.01) between the transport and the Hb decrease after transport, but the activities of T-SOD, U-SOD and RBC-SOD decreased gradually .05). After transport, the difference of the activity of RBC-SOD, T-SOD, CuZn-SOD and U-SOD before transportation was very significant (P <0.01), but no significant difference of Hb (P> 0.05). Conclusion: Acute repeated hypoxia is the main reason that affects the changes of Hb and SOD in vivo and the damage caused by free radicals.