论文部分内容阅读
目的:探讨耐力训练对有氧能力的影响与血管紧张素转化酶(ACE)基因Ⅰ/D(插入/缺失)多态性的关联性,以探寻影响耐力训练敏感性的基因标记。方法:选择102名北方汉族新兵,进行18周的5km跑训练,测定训练前后最大摄氧量(.VO2max)、通气无氧阈(VT)和定量负荷时动态左心室结构与功能指标,并应用PCR-AFLP方法检测其ACE基因Ⅰ/D多态。结果:耐力训练后、.VO2max、VT和左心室结构与功能均发生了良好的顺应性改变;ⅠD型和Ⅱ型的△V.O2max显著高于DD型(P<0.05),△V.O2max的组间差异有显著性(P<0.05),Ⅱ型的△V.O2VT显著高于DD型(P<0.05)。结论:Ⅰ等位基因在.VO2max和VT的训练敏感性方面具有明显的遗传优势,Ⅱ基因型与VT训练敏感性有一定关联,未发现I/D多态性与左心室动态功能指标的训练敏感度之间有关联关系。
Objective: To investigate the relationship between the endurance training aerobic capacity and angiotensin I converting enzyme (ACE) gene Ⅰ / D (insert / deletion) polymorphism in order to explore the gene markers that affect the sensitivity of endurance training. Methods: 102 Northern Han recruits were selected to conduct 18-week 5-km running training. The maximal oxygen uptake (.VO2max), ventilatory anaerobic threshold (VT) and dynamic left ventricular structure and function were measured before and after training. PCR-AFLP method was used to detect the ACE gene I / D polymorphism. RESULTS: After endurance training, the changes of VO2max, VT and left ventricular structure and function all showed good compliance. The △ V.O2max of type Ⅰ and type Ⅱ were significantly higher than those of type DD (P0.05), △ V.O2max (P <0.05). The △ V.O2VT of type Ⅱ was significantly higher than that of DD (P <0.05). CONCLUSION: The I allele has obvious genetic predominance in training sensitivity of VO2max and VT. There is a certain relationship between genotype Ⅱ and VT training sensitivity. No training of I / D polymorphism and left ventricular dynamic function was found Sensitivity has a relationship between.