HDL通过参与胆固醇逆向运输(RCT)而在抗动脉粥样硬化(AS)中起主要作用。本研究首先证实不易感AS动物北京鸭肝中存在HDL受体。 以北京鸭肝细胞膜和细胞为对象。在室温下,~(125)I-HDL可特异地与鸭细胞膜结合,并具有高亲和性(Kd=9.6μg/ml)和可饱和性(Bmax=8.9μg/mg膜蛋白)。4℃时,鸭~(125)I-HDL与培养的鸭肝细胞的特异性结合亦有高亲和性(Kd=7.4μg/ml)和可饱和性(Bmax=5.8μg/mg细胞蛋白)。竞争性抑制 HDL plays a major role in anti-atherosclerosis (AS) through its involvement in reverse cholesterol transport (RCT). This study first confirmed the presence of HDL receptors in duck liver of the less susceptible AS animal. Beijing duck liver cell membranes and cells as the object. ~ (125) I-HDL binds specifically to duck plasma membranes at room temperature with high affinity (Kd = 9.6 μg / ml) and saturability (Bmax = 8.9 μg / mg membrane protein). The specific binding of duck ~ (125) I-HDL to cultured duck hepatocytes also showed high affinity (Kd = 7.4μg / ml) and saturability (Bmax = 5.8μg / mg cell protein) . Competitive inhibition