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目的:探讨慢性阻塞性肺疾病(COPD)与甲状腺激素的相关性。方法:选取90例健康者作为对照组,另选取我院2013年5月至2014年7月期间收治的96例慢性阻塞性肺疾病(COPD)患者作为COPD组,并将COPD组按照病情分为COPD急性发作伴呼吸衰竭组35例、COPD急性发作无呼吸衰竭组31例以及COPD缓解期组30例,采用化学发光微粒子免疫分析方法对选取的所有研究对象的血清三碘甲状腺原氨酸(TT_3)、血清甲状腺素(TT_4)、促甲状腺激素(TSH)、血清游离三碘甲状腺氨酸(FT_3)、血清游离甲状腺素(FT4)水平进行检测,并将检测结果进行分析对比。结果:与健康的对照组相比,COPD组患者的TT_3、TT_4、TSH、FT_3、FT_4水平明显较低(P<0.05);COPD组中急性发作伴呼吸衰竭组患者的TT_3、TT_4、TSH、FT_3、FT_4水平明显低于COPD缓解期组患者(P<0.05);COPD组中急性发作无呼吸衰竭组患者的TT_4、TSH、FT_4水平与COPD缓解期组患者相比无显著性差异(P>0.05),但急性发作无呼吸衰竭组患者的TT3、FT3水平明显低于缓解期组患者(P<0.05)。结论:甲状腺激素水平的变化与慢性阻塞性肺疾病(COPD)患者病情的严重程度有着密切的联系,对患者病情的评估以及预后均具有较大的参考价值。
Objective: To investigate the relationship between chronic obstructive pulmonary disease (COPD) and thyroid hormones. Methods: Ninety healthy subjects were selected as the control group. Another 96 patients with chronic obstructive pulmonary disease (COPD) admitted to our hospital from May 2013 to July 2014 were selected as the COPD group. The patients with COPD were divided into 35 cases of COPD acute respiratory failure group, 31 cases of acute respiratory failure without COPD group and 30 cases of COPD remission group. The chemiluminescence microparticle immunoassay was used to detect the levels of serum triiodothyronine (TT_3 , Serum thyroxine (TT_4), thyrotropin (TSH), serum free triiodothyronine (FT_3) and serum free thyroxine (FT4) were measured. The results were analyzed and compared. Results: The levels of TT_3, TT_4, TSH, FT_3 and FT_4 in patients with COPD were significantly lower than those in healthy controls (P <0.05). The levels of TT_3, TT_4, TSH, The levels of FT_3 and FT_4 in patients with COPD were significantly lower than those in patients with COPD (P <0.05). The levels of TT_4, TSH and FT_4 in COPD patients without acute respiratory failure were not significantly different from those in COPD patients (P> 0.05). However, the levels of TT3 and FT3 in patients with acute respiratory failure without respiratory failure were significantly lower than those in patients with remission (P <0.05). CONCLUSION: The change of thyroid hormone level is closely related to the severity of the disease in patients with chronic obstructive pulmonary disease (COPD), and has great reference value for the evaluation of the patient’s condition and prognosis.