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目的 :将腺病毒介导的野生型 ｐ５３基因 (Ａｄ５/ＣＭＶ/ｐ５３)对非小细胞肺癌 (ＮＳＣＬＣ)和正常人肺成纤维细胞的辐射敏感性进行比较。方法 :①ＮＳＣＬＣ细胞株选用Ａ５４９和Ｈ３２２细胞 ,人肺成纤维细胞株选用ＭＲＣ＿９和ＣＣＤ＿１６细胞。②于裸鼠后腿皮下注射５×
OBJECTIVE: To compare the radiosensitivity of adenovirus-mediated wild type p53 gene (Ad5 / CMV / p53) to non-small cell lung cancer (NSCLC) and normal human lung fibroblasts. Methods: ① NSCLC cell lines were selected A549 and H322 cells, human lung fibroblasts selection MRC_9 and CCD_16 cells. ② nude mice subcutaneous injection of 5 ×