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目的研究职业性焦炉逸散物接触对作业工人肝功能的影响。方法选择河南省某焦化厂焦炉工551人作为暴露组,同时选择该地区无焦炉逸散物职业接触史的128名健康人作为对照组。按照接触焦炉逸散物的时间加权平均浓度将暴露组分为A、B、C 3组,分析不同浓度组工人和对照组的肝功能指标的变化。结果暴露组工人焦炉逸散物时间加权平均浓度的超标率为20.35%;暴露组的丙氨酸氨基转移酶(ALT)活力异常检出率高于对照组(P<0.05);总胆红素(TBIL)和直接胆红素(DBIL)异常检出率与对照组相比,差异无统计学意义。结论长期接触焦炉逸散物可对作业工人的肝功能产生影响,导致ALT活力升高。
Objective To study the effects of occupational coke oven exposure on liver function of workers. Methods 551 coke oven workers in a coking plant of Henan Province were selected as the exposure group. Meanwhile, 128 healthy people without occupational exposure to coke oven in this area were selected as the control group. According to the time-weighted average concentration of exposed coke-oven discharge, the exposed components were divided into A, B and C groups, and the change of liver function indexes of workers in different concentration groups and control group were analyzed. Results The time-weighted average excess concentration of coke oven fugitives in exposed group was 20.35%. The detection rate of alanine aminotransferase (ALT) activity in exposed group was higher than that in control group (P <0.05) There was no significant difference in the detection rate of TBIL and DBIL among the control group. Conclusion Long-term exposure to coke oven discharge may affect the liver function of workers, leading to elevated ALT activity.