The plant NHX gene family encodes Na+/H+ antiporters which are crucial for salt tolerance,potassium homeostasis and cellular pH regulation.Understanding the role of NHX antiporters in membrane trafficking is becoming an increasingly interesting subject of study.Membrane trafficking is a central cellular process during which proteins,lipids and polysaccharides are continuously exchanged among membrane compartments.Yeast ScNhx1p,a prevacuole/vacuolar Na+/H+ antiporter,plays an important role in regulating pH to control trafficking out of the endosome.Evidence begins to accumulate that plant NHX antiporters might function in regulating membrane trafficking in plants.