本文就局部和全身应用头孢唑啉对预防白鼠创口感染的作用作一比较。取体重20～25g的瑞士雌白鼠50只。在背部作长2.5cm的正中切口,切开全厚皮肤,但不切开肉膜。将1ml金黄色葡萄球菌混悬液接种于创口内,用不锈钢夹关闭切口。全身给药的25只白鼠,于背部皮肤切开前1小时向腹膜腔内注射头孢唑啉钠10mg,用盐水30ml冲洗创口。4小时后再给予头孢唑啉钠10mg。局部用药的25只白鼠,也在创口污染后,用30ml盐水冲洗,关闭创口前放入头孢唑啉钠20mg。金黄色葡萄球菌接种量平均为3.38×10~8CFU。全部白鼠于术后 This article on the local and systemic application of cefazolin on the prevention of wound infection in mice for a comparison. Take 50 Swiss female rats weighing 20 ~ 25g. In the back of the incision for the length of 2.5cm, cut full thickness of the skin, but not cut the meat. Inoculate 1ml Staphylococcus aureus suspension in the wound and close the incision with a stainless steel clamp. Twenty-five systemic mice were injected cefazolin sodium 10 mg into the peritoneal cavity 1 hour prior to incision of the dorsal skin and the wound was rinsed with 30 ml of saline. Four hours later given cefazolin sodium 10mg. Topical 25 rats, also contaminated wounds, rinse with 30ml saline, close the wound before placing cefazolin sodium 20mg. Staphylococcus aureus inoculation average of 3.38 × 10 ~ 8CFU. All rats in the postoperative