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目的探讨重症患儿血浆渗透压改变与病情危重度的关系。方法选择2006年12月至2010年12月福建医科大学附属三明第一医院儿科小儿危重病例评分法<80分的重症患儿116例为研究对象,比较血浆渗透压值,分析血浆渗透压改变与病死率的关系。结果高渗组病死率明显高于非高渗组(P<0.01);高渗组重症患儿血浆渗透压值之间差异有统计学意义,危重评分越低,血渗透压越高(P<0.01);随着血浆渗透压升高,病死率渐增高,当血浆渗透压超过330 mmol/L时,随着血浆渗透压升高,病死率明显增加(P<0.01)。累及脏器中,以胃肠和脑功能障碍的病死率最高。结论重症患儿血浆渗透压值越高,病情越严重,病死率明显增加。
Objective To investigate the relationship between the changes of plasma osmotic pressure and the severity of severe illness in critically ill children. Methods From December 2006 to December 2010, Sanming First Affiliated Hospital of Fujian Medical University pediatric critical illness score of 80 cases of severe children with 116 cases as study subjects, comparing the value of plasma osmolality, plasma osmolality and The relationship between mortality. Results The mortality of hyperosmotic group was significantly higher than that of non-hyperosmotic group (P <0.01). The difference of plasma osmotic pressure in hyperosmotic group was statistically significant. The lower the critical score was, the higher the osmotic pressure was (P < 0.01). With the increase of plasma osmotic pressure, the case fatality rate increased gradually. When the osmotic pressure exceeded 330 mmol / L, the mortality increased significantly as the plasma osmotic pressure increased (P <0.01). Involved in organs, the highest mortality of gastrointestinal and brain dysfunction. Conclusions The higher the value of plasma osmotic pressure in critically ill children, the more severe the disease and the higher mortality.