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随着糖皮质激素的广泛应用,糖皮质激素性骨质疏松发病率不断上升。建立一种可靠的动物模型,对研究糖皮质激素性骨质疏松的病因、发病机制及诊断治疗十分必要。现就近年糖皮质激素性骨质疏松模型建模的动物选择、诱导方法、评价指标方等方面作一综述,以期对研究者选择合适的动物模型提供帮助。
With the widespread use of glucocorticoids, the incidence of glucocorticoid osteoporosis continues to rise. To establish a reliable animal model is very necessary for studying the etiology, pathogenesis and diagnosis and treatment of glucocorticoid-induced osteoporosis. In this paper, we review the animal selection, induction methods, evaluation indicators and other aspects of modeling glucocorticoid osteoporosis models in recent years in order to help researchers choose appropriate animal models.