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采用免疫组化 SABC法检测了 4 2例膀胱移行细胞癌患者癌组织标本中 Fas和 Bcl- 2基因的表达情况 ,并观察其与病理分级、临床分期及预后的关系。结果显示 ,Fas基因表达与膀胱移行细胞癌的病理分级、临床分期及是否复发有显著关系 ,Bcl- 2基因表达与临床分期及是否复发有关。认为 Fas和Bcl- 2基因表达可以作为监测膀胱移行细胞癌恶性程度、预测复发的重要指标。在低分化和晚期膀胱移行细胞癌中 ,Fas基因介导的细胞凋亡可能被 Bcl- 2基因的过度表达所抑制。
Immunohistochemical SABC method was used to detect the expression of Fas and Bcl-2 gene in 42 cases of transitional cell carcinoma of the bladder and its relationship with pathological grade, clinical stage and prognosis. The results showed that the expression of Fas gene was associated with the pathological grade, clinical stage and recurrence of bladder transitional cell carcinoma. The expression of Bcl-2 gene was correlated with clinical stage and recurrence. It is considered that Fas and Bcl-2 gene expression can be used as an important index to monitor the malignant degree of transitional cell carcinoma of bladder and predict the recurrence. In poorly differentiated and advanced bladder transitional cell carcinoma, Fas-mediated apoptosis may be inhibited by over-expression of Bcl-2 gene.