蛋白质二硫键异构酶由多种细胞分泌,在生物学代谢过程中具有重要作用,其与糖尿病缺血性心脏病、脑缺血性疾病、血栓性疾病、阿尔茨海默病、白血病、肿瘤等多种疾病的发生发展机制密切相关,现针对蛋白质二硫键异构酶的定义、功能及与相关疾病的关系做一论述。 Protein disulfide isomerase is secreted by a variety of cells and plays an important role in biological metabolism. It is associated with diabetic ischemic heart disease, cerebral ischemic disease, thrombotic disease, Alzheimer’s disease, leukemia, Tumor and other diseases are closely related to the occurrence and development mechanism, now for protein disulfide isomerase definition, function and related diseases to make a discussion.