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目的了解韶关市药品不良反应发生的特点和规律,为临床合理用药提供信息。方法对全市2006年1月1日～2006年12月31日收集并上报的179例药品不良反应报告进行回顾性分析与评价。结果在179例药品不良反应中,涉及91种药品。抗菌药物、注射剂及静脉给药途径是引起不良反应发生的三大主要因素。ADR涉及的系统/器官以皮肤及附件损害占首位,消化系统反应及神经系统反应次之。结论加强药品不良反应监测及其相关知识的宣传,这对促进临床合理用药,降低ADR的发生率,保障人民用药安全,具有重要意义。
Objective To understand the characteristics and rules of adverse drug reactions in Shaoguan City and provide information for clinical rational drug use. Methods A retrospective analysis and evaluation of 179 adverse drug reactions reports collected and reported from January 1, 2006 to December 31, 2006 in the city were made. Results in 179 cases of adverse drug reactions, involving 91 kinds of drugs. Antimicrobial drugs, injections and intravenous routes of administration are the three major causes of adverse reactions. The systems / organs involved in ADR have the highest damage to the skin and appendage, followed by the digestive system reaction and nervous system reaction. Conclusion Strengthening the monitoring of adverse drug reactions and the publicity of related knowledge is of great significance for promoting clinical rational drug use, reducing the incidence of ADR and ensuring people’s medication safety.