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目的探讨年龄因素对中老年妇女腰椎双能X线骨密度(DXA)测量重复性的影响。方法用数字法随机选取90例中老年女性受检者,按年龄分为3组:45～55岁、56～65岁、66～75岁组,每组30例。每例受检者均在同一天内完成2次腰椎DXA测量,DXA机型为美国Lunar公司生产的Prodigy型骨密度仪。根据公式计算每例个体的标准差、变异系数及每组患者的平均骨密度、标准差,并对结果进行方差分析。用标准差代表精确性,P<0.05为差异有统计学意义。结果45～55岁、56～65岁、66～75岁各组的平均骨密度分别为(1.089±0.014)g/cm2、(0.992±0.010)g/cm2、(0.910±0.010)g/cm2,随年龄的增长,各年龄组的平均骨密度下降,56～65岁和66～75岁年龄组的标准差相同,但2年龄组的标准差低于45～55岁组的标准差。三组间骨密度差异有统计学意义(F=5.213,P<0.05)。45～55岁与56～65岁组、45～55岁与66～75岁组、56～65岁与66～75岁组间两两比较差异均有统计学意义(q值分别为0.035、0.035、0.500,P值均<0.05)。结论年龄因素可影响中老年女性腰椎DXA测量的精确性。
Objective To investigate the effect of age on the reproducibility of measurement of lumbar dual-energy X-ray absorptiometry (DXA) in middle-aged and elderly women. Methods Ninety middle-aged and elderly women were randomly selected by digital method and divided into three groups according to their age: 45-55 years old, 56-65 years old, 66-75 years old group, 30 cases in each group. Each subject completed two measurements of lumbar DXA on the same day. The DXA model was a Prodigy-type bone densitometer manufactured by Lunar Corporation of America. The standard deviation, coefficient of variation and mean bone mineral density (BMD) and standard deviation (ANOVA) of each individual were calculated according to the formula, and the results were analyzed for variance. The standard deviation of accuracy, P <0.05 for the difference was statistically significant. Results The average BMD of 45-55, 56-65 and 66-75 years were (1.089 ± 0.014) g / cm2, (0.992 ± 0.010) g / cm2 and (0.910 ± 0.010) g / cm2, With age, average bone mineral density decreased for all age groups, while standard deviations for age groups 56-65 and 66-75 were similar, but standard deviations for age 2 were lower than those for age 45-55. There was significant difference in bone mineral density among the three groups (F = 5.213, P <0.05). 45 to 55 years old and 56 to 65 years old group, 45 to 55 years old and 66 to 75 years old group, 56 to 65 years old and 66 to 75 years old group between the two groups were statistically significant differences (q values were 0.035,0.035 , 0.500, P <0.05). Conclusion Age can influence the accuracy of DXA measurement in middle-aged and elderly women.