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目的:采用尿酸钠(MUS)诱导的大鼠急性痛风性关节炎模型,研究痹清胶囊治疗急性痛风性关节炎作用机理。方法:采用ELISA方法测定踝关节液白细胞介素12(IL-12)的含量及采用免疫组化方法测定大鼠踝关节诱导型环氧化酶(COX-2)的表达。结果:痹清胶囊明显降低痛风性关节炎模型大鼠踝关节IL-12的含量、抑制大鼠踝关节COX-2的表达。结论:痹清胶囊治疗痛风性关节炎有确切疗效,可能与降低IL-12的含量、抑制COX-2的表达有关。
OBJECTIVE: To study the mechanism of the treatment of acute gouty arthritis with sodium uric acid (MUS)-induced acute gouty arthritis in rats. METHODS: The content of interleukin-12 (IL-12) in the ankle joint fluid was determined by ELISA and the expression of COX-2 in the ankle joint of rat was measured by immunohistochemistry. RESULTS: Minqing Capsule significantly reduced the content of IL-12 in the ankle joint and inhibited the expression of COX-2 in the ankle joint of rats with gouty arthritis. Conclusion: The clear therapeutic effect of Geng Qing Capsule on gouty arthritis may be related to the decrease of IL-12 and the inhibition of COX-2 expression.