既往报道,在巯甲丙脯酸引起肾功能不全的许多病例中都联用利尿剂,故提示在肾灌注压持续下降的情况下,利尿剂或钠消耗均可能有助于血管紧张素转换酶抑制剂引起的肾小球滤过率(GFR)下降。本文旨在研究移植肾动脉狭窄患者在钠耗竭和钠饱和的情况下,巯甲丙脯酸对肾血液动力学的影响。患者男性,27岁,有慢性肾小球肾炎病史伴终末期肾病,于同种异体肾移植后8个月出现严重高血压,应用心得安、肼苯哒嗪和双氢克尿噻均无效。经移植肾血管造影提示,移植肾动脉在端-端吻合处附近狭窄达90%以上。患者测试前6天起饮食含钠为60mEq/d,并停用上述药物。测试期间监测血尿素氮、血肌酐、体重及血压,并分别于第1天(钠耗竭)、第2天(钠耗 It has been previously reported that many cases of renal insufficiency caused by captopril are associated with diuretics, suggesting that diuretic or sodium consumption may contribute to angiotensin-converting enzyme Inhibitors cause glomerular filtration rate (GFR) decreased. This article aims to investigate the effects of captopril on renal hemodynamics in patients with renal transplant stenosis under sodium depletion and sodium saturation. A 27-year-old man with a history of chronic glomerulonephritis and end-stage renal disease developed severe hypertension at 8 months after allogeneic kidney transplantation and was refractory to propranolol, hydralazine and hydrochlorothiazide. Transplantation of renal angiography prompted the renal graft in the end - anastomosis near the stenosis of more than 90%. Six days before the patient’s diet, sodium diet was 60 mEq / d, and the above drugs were discontinued. During the test, blood urea nitrogen, serum creatinine, body weight and blood pressure were monitored. On the first day (sodium depletion), the second day (sodium consumption