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腹腔手术后肠粘连，占各类肠梗阻的３７～６４％。为探讨通腑泻热灌肠合剂对术后肠粘连的作用机制，本实验采取大白鼠小肠浆膜镊子夹取损伤的方法制成肠粘连模型，将模型随机分成三组：通腑泻热合剂灌肠组，生理盐水灌肠组和空白对照组，术后连续灌肠２天，术后第６天检测结果。实验结果表明：通腑泻热合剂灌肠组与生理盐水灌肠组及对照组比较，能够明显减少肠粘连的处数（Ｐ＜０．０１），降低纤维蛋白原的含量（Ｐ＜０．０５），同时提高血谷胱甘肽歧化酶（ＧＳＨ－Ｐｘ）的含量（Ｐ＜０．０５），而血超氧化物歧化酶（ＳＯＤ）的含量无显著差异。结果提示：通腑泻热灌肠合剂能够降低纤维蛋白原，抑制纤维蛋白产生，降低组织炎症反应；同时，提高ＧＳＨ－Ｐｘ的含量，减少强氧化性的自由基对组织的损伤，加强机体防御自由基损伤的第二道防线，防止炎症的发生，从而达到预防粘连的目的。
Intestinal adhesion after abdominal surgery, accounting for various types of intestinal obstruction of 37 to 64%. In order to investigate the mechanism of Tongfu Xiezheng enema mixture on postoperative intestinal adhesion, in this experiment, the intestinal mucosa model was made by taking the small intestine serosal tweezers and then the model was randomly divided into three groups: Tongfuxie heat enema Group, saline enema group and blank control group, continuous enema for 2 days after operation, the test results on the 6th day after operation. The experimental results showed that Tongfu Xiere Mixture enema group could significantly reduce the number of intestinal adhesion (P <0.01) and fibrinogen content (P <0.05) compared with saline group and control group. (P <0.05), while the level of serum superoxide dismutase (SOD) had no significant difference. The results suggest that Tongfu Xiere Decoction can reduce fibrinogen, inhibit the production of fibrin and reduce the inflammatory reaction of tissues. At the same time, it can increase the content of GSH-Px, reduce the damage of strong oxidizing radical to tissues and strengthen the defense of body The second line of basic damage prevention, to prevent the occurrence of inflammation, so as to achieve the purpose of preventing adhesions.