本文报道了一例精神病患者应用奋乃静治疗(8mg,2/日,血浆浓度2～3nmol/L)使病情稳定,而本品与双硫醒并用时发生严重的相互作用。奋乃静的血浆浓度下降(在1nmol/L以下),导致精神病症状复发。即使应用双倍剂量的奋乃静无论是对血浆浓度还是治疗效应均无改变。当双硫醒与奋 This article reports the use of perphenazine (8 mg, 2 / day, plasma concentrations of 2 to 3 nmol / L) in one patient with psychosis to stabilize the condition and a serious interaction with this substance when used in combination with bisulfate. Perphenazine plasma concentration decreased (below 1nmol / L), leading to recurrence of psychotic symptoms. Even if double doses of perphenazine were used, there was no change in plasma concentration or therapeutic effect. When the dual-waking and excited