转甲状腺素蛋白相关心脏淀粉样变(ATTR-CA)是淀粉样蛋白在心肌细胞间隙沉积所致，其临床表现缺乏特异性，早期识别、诊断和治疗困难，严重影响患者的生活质量和生存率。随着近年来无创诊断技术的进步和有效药物的问世，早期诊断并指导正确治疗可显著改善患者预后。n 99Tcn m-焦膦酸盐(PYP)可用于ATTR-CA的无创诊断，其标准化图像采集和分析对临床应用至关重要。中华医学会核医学分会心脏学组及国家核医学专业质控中心基于国内外有关ATTR-CA n 99Tcn m-PYP SPECT(/CT)显像的经验和研究进展，制定了符合我国诊疗常规、适宜在我国临床推广的核医学显像操作规范，以期提高我国诊治ATTR-CA的整体水平。n “,”Transthyretin-related cardiac amyloidosis (ATTR-CA) is caused by the deposition of amyloid protein in the intercellular space of cardiomyocytes. Due to the lack of specificity of clinical manifestations and the barriers of early identification, diagnosis and treatment seriously affect the survival rate and life quality of patients. With the developments of noninvasive diagnostic technologies and effective drugs in recent years, timely diagnosis and precise treatment significantly improve the prognosis of patients. n 99Tcn m-pyrophosphate (PYP) can visualize ATTR-CA noninvasively, and the standardized acquisition and image analysis are very critical for the clinical application. This article highlights the recommendations on n 99Tcn m-PYP SPECT (/CT) imaging of ATTR-CA based on the local and global imaging experience and research progress, in order to in line with Chinese clinical conditions of diagnosis and treatment for more convenient promotion.n