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我院附属口腔医院樊明文副教授于1981至1983年在加拿大访问学习期间所完成的《缺乏乳酸脱氢酶活性的变链突变菌株的竞争能力研究》一文,最近,经国内有关专家评审认为,该研究达到了同类研究的国际先进水平,若能深入研究下去,有可能产生一种减毒活疫苗糖丸来预防龋病。龋病是人类中发病率最高的一种疾病,在我国平均龋患率高达37.3％。关于龋病病因,早在一百年前就有人提出了“酸原性学说”,即由变形链球菌产生的大量乳酸所致。半个多世纪以来,有许多学者试图按这一理论寻求一种有效的方法预防龋病,但均未取得良好效果。1978年Millman首先提出用缺乏乳酸脱氢酶活性的突
Recently, according to a review by the relevant experts in the country, Fan Mingwen, an associate professor of oral stomatology in our hospital, conducted a study on the competitive ability of a mutant with a mutation lacking lactate dehydrogenase activity during his visit to Canada from 1981 to 1983. Research reached the international advanced level of similar research, if we can further study, it is possible to produce a live attenuated vaccine sugar pills to prevent dental caries. Caries is the highest incidence of human disease, a caries in our country average rate as high as 37.3%. As to the cause of dental caries, “acidity theory” was proposed as early as one hundred years ago, that is, a large amount of lactic acid produced by Streptococcus mutans. For more than half a century, many scholars have tried to find an effective way to prevent dental caries according to this theory, but none of them have achieved good results. In 1978, Millman first proposed the use of sudden lack of lactate dehydrogenase activity