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砷化物具有较广泛的抗瘤谱 ,砷化物可能通过下列途径发挥其抗癌生物效应 :①砷与影响细胞呼吸、氧化、代谢和生长的重要酶类的巯基 (_SH)相结合 ,干扰SH酶的活性 ,包括线粒体的功能、半胱氨酸基酶、酪氨酸激酶、丝裂原激活的蛋白激酶、鸟氨酸脱羧酶、DNA修复酶等 ;②调控癌的相关基因的表达 ,影响Bcl_2、p53、Bax、Bcl_x、Fas、C_myc、p16、p21、p38和p15等 ;③砷能使纺缍体结构破坏 ,抑制微管聚合以及影响周期素、周期素依赖激酶 (CDK)和CDK抑制蛋白等多种途径 ,使癌细胞阻抑在G/M或S期 ,致使生长受阻或发生凋亡
Arsenide has a broader anti-tumor spectrum, arsenide may exert its anti-cancer biological effects through the following ways: ① arsenic and the impact of cell respiration, oxidation, metabolism and growth of key enzymes in the sulfhydryl group (_SH), interfering with SH enzyme Including mitochondrial function, cysteine-based enzyme, tyrosine kinase, mitogen-activated protein kinase, ornithine decarboxylase, DNA repair enzyme, etc .; ② regulate the expression of cancer related genes, affecting Bcl_2 , P53, Bax, Bcl_x, Fas, C_myc, p16, p21, p38, p15 and so on; ③ Arsenic could destroy the structure of spinosad and inhibit the polymerization of microtubules and the effects of cyclophilin, cyclin dependent kinase (CDK) A variety of ways, so that cancer cells suppressed in the G / M or S, resulting in growth retardation or apoptosis