青霉胺治疗的副作用据报道有腹痛,味觉障碍,皮肤反应以及肾、骨髓和外周神经的损害等。作者对12名年龄35～68岁患慢性多关节炎的妇女用青霉胺治疗2～11月后,均发生肌无力。5例为单纯眼型。7例为全身型,均迅速进展至Ⅱa和Ⅱb期(Ossermann),其中2例达到Ⅲ期。所有病例的腾喜龙试验均阳性。多数病例的肌刺激图都显示肌无力的特征。3例在停用青霉胺后肌无力症状消失,再用后又迅速复发,潜伏期更短,其中1例因呼吸停止死亡。3例曾作肌肉活检,发现有间质性或血管周围圆细胞浸润和部分肌纤维萎缩。5例的肌肉抗体检查中,1例疑为阳性。6例抗核因子检查均阴性。5例曾作肺纵隔X线摄 Side effects of penicillamine treatment Abdominal pain, dysgeusia, skin reactions, and damage to the kidneys, bone marrow, and peripheral nerves are reported. The authors of 12 women aged 35 to 68 years suffering from chronic polyarthritis with penicillin treatment 2 to 11 months after the occurrence of muscle weakness. 5 cases of simple eye type. Seven cases of systemic type, were rapidly progressed to Ⅱ a and Ⅱ b period (Ossermann), of which 2 cases reached stage Ⅲ. All cases of Teng-Long test were positive. Muscle stimulation charts in most cases show signs of muscle weakness. Three patients discontinued penicillamine after the disappearance of myasthenia gravis, and then quickly relapsed, the incubation period is shorter, of which 1 died due to respiratory arrest. Three cases had a muscle biopsy and found to have interstitial or perivascular round cell infiltration and some muscle fiber atrophy. In 5 cases of muscle antibody test, 1 case was suspected positive. 6 cases of anti-nuclear factor test were negative. 5 cases had lung mediastinoscopy X-ray