临床确诊为系膜增生性肾小球肾炎（ＭｓＰＧＮ）的１１８例分为轻、中、重３组。从每组中随机抽取８例作为实验组，取３例正常肾组织作为对照组。然后对所选取的２７例进行免疫电镜检查。结果显示：正常及空白对照组肾小球内未见金颗粒，轻度ＭｓＰＧＮ的系膜细胞（ＭＣ）内Ｇｏ、ＲＥＲ附近有少量散在分布的金颗粒；中度ＭｓＰＧＮ增生的ＭＣ内金颗粒数增多，Ｇｏ、ＲＥＲ及Ｌｙ附近与轻度比较有显著性差异（Ｐ＜０００１）；重度ＭｓＰＧＮ增生的ＭＣ内见有大量金颗粒聚集呈团、线状或散在分布，与轻、中度ＭｓＰＧＮ比较均有显著性差异（Ｐ＜０００１）。以上结果表明肿瘤坏死因子α（ＴＮＦα）可由ＭＣ产生，随着病变进展ＴＮＦα在ＭＣ内逐渐增多 Clinically diagnosed as mesangial proliferative glomerulonephritis (MsPGN) of 118 cases were divided into mild, moderate and severe 3 groups. From each group randomly selected 8 cases as experimental group, take 3 cases of normal kidney tissue as control group. Then select the 27 cases of immunoelectron microscopy. The results showed that there was no gold particles in the glomeruli of the normal and blank control groups, few scattered gold particles around the mesangial cells (MC) of mild MsPGN and scattered gold particles around the RER; (P <0001). There was a large number of gold particles aggregated, linear or scattered in MC with severe MsPGN hyperplasia, which was similar to mild, moderate MsPGN were significantly different (P <0001). The above results show that tumor necrosis factor α (TNFα) can be generated by MC, with the progression of TNFα gradually increased in the MC