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目的探讨胃癌组织中NOB1的表达及其临床意义。方法采用免疫组化SP法检测70例胃癌组织和对应的经病理检查无明显异常的胃切缘组织(作为对照组)中NOB1的表达情况,并分析其与胃癌患者临床病理特征的关系。结果 70例胃癌组织中NOB1的阳性表达率为65.7%(46/70)高于切缘胃黏膜中NOB1的阳性表达率(47.1%,33/70)(P<0.05)。不同分化程度和临床分期的胃癌组织中NOB1蛋白阳性率存在显著性差异(P<0.05),有淋巴结转移和远处转移者分别高于无淋巴结转移和远处转移者(P<0.05)。结论胃癌组织中NOB1蛋白表达上调,并与胃癌的分化程度、临床分期、淋巴结转移和远处转移有关。
Objective To investigate the expression of NOB1 in gastric carcinoma and its clinical significance. Methods Immunohistochemical SP method was used to detect the expression of NOB1 in 70 cases of gastric carcinoma and its corresponding gastric margin tissue without obvious abnormality as a control group. The relationship between the expression of NOB1 and the clinicopathological features of gastric cancer was analyzed. Results The positive expression rate of NOB1 in 70 cases of gastric carcinoma was 65.7% (46/70), which was higher than that of NOB1 in the marginal gastric mucosa (47.1%, 33/70) (P <0.05). The positive rates of NOB1 protein in gastric cancer tissues with different degrees of differentiation and clinical stage were significantly different (P <0.05), those with lymph node metastasis and distant metastasis were respectively higher than those without lymph node metastasis and distant metastasis (P <0.05). Conclusion The up-regulation of NOB1 protein in gastric cancer is related to the differentiation, clinical stage, lymph node metastasis and distant metastasis of gastric cancer.