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本研究利用大鼠模型探索抗艾滋病辅助治疗中成药唐草片对抗病毒药洛匹那韦药代动力学的影响。大鼠随机分为洛匹那韦组(36 mg/kg)和唐草片联用洛匹那韦组(LPV:36 mg/kg,Tang herb:864 mg/kg),灌胃给药,高效液相色谱法测定给药前后0,0.5,1,2,4,8,10,12,14,16,22小时的血药浓度,计算药动学参数。结果显示:唐草片与洛匹那韦合并用药后,洛匹那韦的峰浓度Cmax和曲线下峰面积AUC显著提高(P<0.05)、半衰期t1/2z和达峰时间Tmax延长(P>0.05)。本研究提示唐草片可延迟洛匹那韦的吸收、推迟达峰时间、提高生物利用度,具体作用机制需要深入研究,临床用药需要考虑相互作用。
In this study, a rat model was used to explore the effect of the anti-AIDS adjuvant treatment of Chinese herb Tangmai tablet on the anti-viral drug lopinavir pharmacokinetics. The rats were randomly divided into Lopinavir group (36 mg / kg) and Tang grass slice combined with Lopinavir group (LPV: 36 mg / kg, Tang herb: 864 mg / kg) Determination of plasma concentrations of 0, 0.5, 1, 2, 4, 8, 10, 12, 14, 16 and 22 hours before and after administration, and the pharmacokinetic parameters were calculated. The results showed that the peak concentration Cmax and peak area AUC of lopinavir were significantly increased (P <0.05), and the half-life t1 / 2z and peak time Tmax were prolonged (P> 0.05 ). This study suggests that Tangcao Tablet can delay the absorption of lopinavir, postpone the peak time, improve bioavailability, the specific mechanism of action needs further study, clinical medication need to consider the interaction.