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目的和方法：采用家兔失血性休克／再灌注（Ｓ／Ｒ）模型，以放射免疫法分析了动物血清中磷脂酶Ａ２及其活性产物血栓素（ＴＸＢ２）、前列环素（ＰＧＩ２）在损伤过程中的变化规律，同时观察了氯喹及其同类化合物磷酸萘酚喹、抗氧化剂黄芪酮对Ｓ／Ｒ损伤后上述ＰＬＡ２活性产物的影响。结果：氯喹可明显降低ＰＬＡ２，使ＴＸＢ２／ＰＧＩ２比值恢复于接近正常；磷酸酚喹和黄芪酮也可明显降低ＰＬＡ２，使ＴＸＢ２／ＰＧＩ２比值显著低于Ｓ／Ｒ损伤组：ＨＣＯ－３和ｔＣＯ２也得以接近于正常水平。结论：Ｓ／Ｒ过程中ＴＸＢ２的增高导致的ＴＸＢ２／ＰＧＩ２比值改变可能对循环有重要影响；氯喹类化合物及环氧化物酶抑制剂可能通过抑制ＰＬＡ２活性及降低ＴＸＢ２／ＰＧＩ２比值，促进全身循环和呼吸系统功能恢复正常
PURPOSE AND METHODS: Phospholipase A2 (TXB2) and prostacyclin (PGI2) in animal serum were analyzed by radioimmunoassay in rabbit hemorrhagic shock / reperfusion (S / R) The changes in the process of S / R were also observed. The effects of chloroquine and its analogues of naphthoquine and antioxidants on the activity of PLA2 after S / R injury were also observed. Results: Chloroquine significantly decreased PLA2 and restored the TXB2 / PGI2 ratio to near normal levels. Phenolic and phosphodiesterase also decreased PLA2, significantly lower the ratio of TXB2 / PGI2 to S / R injury: HCO-3 and tCO2 To be close to normal levels. CONCLUSIONS: The change of TXB2 / PGI2 ratio caused by the increase of TXB2 during S / R may have an important effect on circulation. Chloroquine and epoxide inhibitors may promote systemic circulation by inhibiting PLA2 activity and decreasing TXB2 / PGI2 ratio Respiratory system function returned to normal