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在泰国不断出现抗氯喹、法西达和奎宁的恶性疟患者。为此急需寻求一种有效治疗方案。作者等采用氨酚喹-四环素配伍疗法,在泰国中部对恶性疟患者进行了临床试验。受试对象是于1981年5月～10月从医院确诊为恶性疟的患者中选出。受试者至少需住院7天。患者于入院当天,即服用氨酚喹,总剂量为2400mg(基质),疗程5天。服法:第1天服2次,每次服400mg;以后4天均为每天2次,每次200mg。同时于第1天开始加服四环素,每天1.0g,分4次服,连服7天。患者于入院当天治疗前先作厚、薄血膜检查,以确定疟原虫种类和密度;治疗期间,每天作厚血膜检查;出院后要求患者来院作
In Thailand, there continues to be cases of falciparum malaria against chloroquine, faxidamic and quinine. Therefore urgently needs to seek an effective treatment plan. The authors used paracetamol-tetracycline compatibility in clinical trials of patients with falciparum malaria in central Thailand. Subjects were selected from patients diagnosed with falciparum malaria in the hospital from May to October 1981. Subjects need to be hospitalized for at least 7 days. Patients on the day of admission, that is taking paracetamol, the total dose of 2400mg (matrix), the course of treatment for 5 days. Method: the first day of service 2 times, each serving 400mg; after 4 days are 2 times a day, each 200mg. At the same time on the first day plus tetracycline, 1.0g daily, 4 times service, and even served 7 days. Patients on the day of admission before treatment for thick, thin blood film examination to determine the type and density of Plasmodium; during treatment, daily thick film examination; patients were asked to hospital after discharge