AIM: To evaluate the pain relieving effect of intervention with “Lamaze method of colonoscopy” in the process of colonoscopy.METHODS: Five hundred and eighty-five patients underwent colonoscopy were randomly divided into three groups, Lamaze group, anesthetic group and control group. Two hundred and twenty-four patients of Lamaze group, the “Lamaze method of colonoscopy” were practiced in the process of colonoscopy. The Lamaze method of colonoscopy is modified from the Lamaze method of childbirth, which helped patients to relieve pain through effective breathing control. One hundred and seventy-eight patients in anesthetic group accepted sedation colonoscopy. For 183 patients in control group, colonoscopy was performed without any intervention. The satisfactory of colon cleaning, intestinal lesions, intubation time, success ratio, pain grading and complications were recorded. All data were statistically analyzed.RESULTS: There were no significant differences at base line of the three groups(P > 0.05). Anesthetic group shows advantage in intubation time than the other two groups(P < 0.05). Lamaze group shows no advantagein intubation time than that in control group(P > 0.05). The anesthetic group showed an apparent advantage in relieving pain(P < 0.01). Therefore, the “Lamaze method of colonoscopy” performed in colonoscopy could relieve pain effectively comparing with control group(P < 0.05). The patients in anesthetic group had the highest incidence of complications(P < 0.05).CONCLUSION: The performance of the “Lamaze method of colonoscopy” in the process of colonoscopy could relieve patients’ pain, minimize the incidence of complications, and is worthy promotion in clinical practice. AIM: To evaluate the pain relieving effect of intervention with “Lamaze method of colonoscopy ” in the process of colonoscopy. METHODS: Five hundred and eighty-five patients underwent colonoscopy were randomly divided into three groups, Lamaze group, anesthetic group and control group. Two hundred and twenty-four patients of Lamaze group, the “Lamaze method of colonoscopy” were practiced in the process of colonoscopy. The Lamaze method of colonoscopy is modified from the Lamaze method of childbirth, which helped patients to relieve pain Through effective breathing control. One hundred and seventy-eight patients in anesthetic group accepted sedation colonoscopy. For 183 patients in control group, colonoscopy was performed without any intervention. The satisfactory of colon cleaning, intestinal lesions, intubation time, success ratio, pain grading and complications were recorded. There were no significant differences at base line of the thr Anesthetic group shows advantage in intubation time than the other two groups (P <0.05). Lamaze group shows no advantage in intubation time than that in control group (P> 0.05). The anesthetic group showed an apparent The patients in anesthetic group had the highest incidence of complications (P <0.05). P <0.05). CONCLUSION: The performance of the “Lamaze method of colonoscopy ” in the process of colonoscopy could relieve patients’ pain, minimize the incidence of complications, and is worthy promotion in clinical practice.