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CGP56697是一种口服的、用蒿甲醚和苯芴醇按固定剂量配伍的复方,该药产于中国,已用于治疗恶性疟病人。单用蒿甲醚治疗恶性疟病人常发生复燃,苯芴醇是一种高效抗疟药,但作用缓慢。把蒿甲醚的快速作用和苯芴醇的高治愈率相结合是合理的。作者选择坦桑尼亚Ifakara某医院门诊的260名患恶性疟儿童为研究对象,用该药治疗,并对其效果和安全性进行评价。
CGP56697 is an orally administered compound in a fixed dose with artemether and lumefantrine, a drug produced in China that has been used in the treatment of patients with P. falciparum. In the treatment of falciparum malaria with artemether alone, there is often a relapse, and lumefantrine is an effective anti-malarial drug, but its effect is slow. It is reasonable to combine the rapid action of artemether with the high cure rate of lumefantrine. The authors selected 260 patients with falciparum malaria from a clinic in a hospital in Ifakara, Tanzania, as subjects to be treated with the drug and evaluated its efficacy and safety.