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取四种异物(不锈钢、塑料、铜丝、硅胶)置于兔子宫内,观察异物对胚泡着床、宫腔内环境及子宫内膜局部组织的形态学的影响。结果:(1)凡四种不同异物所在处均无胚泡着床,(2)子宫腔洗液中蛋白氮、白细胞计数及其分类、免疫反应与血凝因子的变化无统计学意义,但发现蛋白氮含量与中性粒细胞成正相关;(3)经显微镜、扫描电镜、透射电镜观察,见内膜表面腺体的分泌物增多,形成之屏障覆盖于内膜表面。内膜表面有糜烂及溃疡面,并伴有白细胞浸润;(4)偶见内膜坏死、出血。提示异物抗生育的作用在于阻碍胚泡着床,而影响胚泡着床的原因则在于异物对局部引起的机械性压迫或刺激的组织反应。
Take four kinds of foreign body (stainless steel, plastic, copper wire, silicone) placed in the rabbit uterus to observe the impact of foreign body on the implantation of the blastocyst, uterine environment and the morphology of the local tissue of the endometrium. RESULTS: (1) There was no blastocyst implantation in any of the four different foreign bodies. (2) There was no significant difference in protein nitrogen and white blood cell count, classification of immune cells and blood coagulation factors in uterine cavity lotion Found that protein nitrogen content and neutrophils are positively correlated; (3) by microscopy, scanning electron microscopy, transmission electron microscopy, see the secretion of endometrial gland secretions, the formation of the barrier covering the endometrial surface. Endometrial erosion and ulcers on the surface, accompanied by leukocyte infiltration; (4) occasionally seen intimal necrosis, bleeding. Prompted the role of foreign body anti-fertility is hindered embryo implantation, and the impact of blastocyst implantation lies in the foreign body caused by local mechanical compression or stimulation of the tissue response.