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目的对疑似类风湿性关节炎(RA)患者进行抗环瓜氨酸肽(CCP)抗体及类风湿因子(RF)联合检测,以提高RA的诊断率。方法 CCP抗体利用ELISA法,RF利用免疫比浊法。对59例患病2年以上RA患者和158例早期疑似RA进行对照检测。结果抗CCP抗体、RF及两者联合检测在患病2年以上RA患者中的阳性率分别为45.8%、44.1%和69.5%,在早期疑似患者的阳性率分别为60.1%、64.6%及81.0%,联合检测与单项检测阳性率比较,差异均有统计学意义(P均<0.01)。结论抗CCP抗体和RF联合检测可明显提高RA的诊断率。
Objective To detect anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor (RF) in patients with suspected rheumatoid arthritis (RA) to improve the diagnostic rate of RA. Methods CCP antibodies were detected by ELISA and RF by immunoturbidimetric assay. A total of 59 patients with RA more than 2 years and 158 patients with early suspected RA were tested. Results The positive rates of anti-CCP, RF and their combined detection in patients with RA more than 2 years were 45.8%, 44.1% and 69.5%, respectively. The positive rates of anti-CCP, anti-CCP and anti-CCP were 60.1%, 64.6% and 81.0% %. The positive rates of combined detection and single detection were significantly different (all P <0.01). Conclusion Anti-CCP antibody and RF combined detection can significantly improve the diagnostic rate of RA.