药物反应个体差异是药物治疗中的普遍现象,也是临床药物治疗失败的重要原因。个别患者对常规药物治疗非常敏感而出现各种程度不等的药物不良反应的情况也十分普遍,这些异常药物反应是由许多特殊基因型构成的特定基因型组所决定的,是目前药物基因组学需要明确的研究内容。现依据有关文献分析,归纳、总结药物基因组学的发展、研究内容及与个体化给药的关系,为安全、合理用药提供理论依据。 Drug reactions Individual differences in drug treatment is a common phenomenon, but also an important reason for the failure of clinical drug treatment. It is also common that individual patients are very sensitive to conventional medical therapy and have varying degrees of adverse drug reactions that are determined by a particular genotype of many particular genotypes and are currently pharmacogenomics Need a clear research content. Now based on the literature analysis, induction, summarize the development of drug genomics, research content and the relationship with individualized administration, to provide a theoretical basis for safe and rational drug use.