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~3H-胸腺嘧啶核苷(~3H-胸苷)具有广泛的生物学活性,在放射生物学和生物化学的研究中已普遍应用,但对它的毒性至今还没有统一的看法。本文把它和氚氧化物以及非放射性的胸腺嘧啶核苷(胸苷)作比较,来评价它的毒性。实验把上述三种化合物分成若干剂量组,每个剂量组用23～25克雌性小鼠10只,观察腹腔注射后动物的一般状态、外周血相、寿命和LD_(50)/_(30)值。结果表明,~3H-胸苷比氚氧化物毒性更大,表现在:1.死亡率较高,寿命缩短。剂量为0.6毫居里/
~ 3H-thymidine (~ 3H-thymidine) has a wide range of biological activity, has been widely used in radiobiological and biochemical studies, but its toxicity has so far not a unified view. It is compared with tritiated oxides and non-radioactive thymidine (thymidine) to evaluate its toxicity. Experiments divided the above three compounds into several dose groups, and each dose group used 10 mice from 23 to 25 grams to observe the general state, peripheral blood phase, life expectancy and LD50 / 30 value after intraperitoneal injection . The results showed that ~ 3H-thymidine is more toxic than tritiated oxide, manifested in: 1. Higher mortality and shortened life expectancy. A dose of 0.6 millicuries /