论文部分内容阅读
用比色分析法测定了 132名正常成人及 2 3例各种病因引起的肝硬化患者的血清生物素基酶活性 ,以探讨其与肝脏受损害程度的关系及其临床意义。结果表明肝病患者的血清生物素基酶活性显著低于正常人 ,其生物素基酶活性为 (3 5 5± 0 82 )nmolmin-1血清ml-1(正常对照为 (7 33± 1 5 5 )nmol·min-1·血清ml-1)。血清生物素基酶活性与血清白蛋白浓度 ,凝血酶原时间和血清总胆固醇浓度分别相关 (r =0 6 ,P <0 0 0 3;r=- 0 5 0 9,P<0 0 13;r =0 76 4,P <0 0 0 1)。因此血清生物素基酶活性可反映肝脏受损程度及其预后 ,有一定的临床意义。
The serum biotin-based enzyme activity of 132 normal adults and 23 patients with cirrhosis caused by various etiologies was measured by colorimetric assay to investigate its relationship with the extent of liver damage and its clinical significance. The results showed that patients with liver disease serum biotin-based enzyme activity was significantly lower than normal, the biotin-based enzyme activity was (3 5 5 ± 0 82 nmolmin-1 serum ml-1 (normal control was (7 33 ± 1 5 5 ) nmol · min-1 · serum ml-1). Serum biotin-based enzyme activity was correlated with serum albumin concentration, prothrombin time, and serum total cholesterol concentration (r = 0 6, P <0 0 0 3; r = - 0 509, P 0 01; r = 0 76 4, P <0 0 0 1). Therefore, serum biotin-based enzyme activity can reflect the degree of liver damage and prognosis, has some clinical significance.