埃博霉素是继紫杉醇之后新一代的微管蛋白抑制剂,被认为是目前最有希望的抗癌药物之一。但是,目前发酵产量较低,化学合成步骤多,不能实现工业化生产。相比较而言,埃博霉素的异源表达有很多优点,比如异源宿主代时较短,易于基因工程操作等。在异源宿主中产生埃博霉素已经成为目前研究的一个热点。本文综述了近年来埃博霉素在天蓝色链霉菌(S.coelicolor),大肠杆菌(E.coli)和橙黄色黏球菌(M.xanthus)等宿主中表达的研究进展以及面临的机遇和挑战。 Epothilone, a new generation of tubulin inhibitors after paclitaxel, is considered as one of the most promising anti-cancer drugs. However, the current fermentation yield is low, chemical synthesis steps, can not achieve industrial production. In contrast, heterologous expression of epothilone has many advantages, such as shorter generation of heterologous host generation, easy genetic engineering operations. The generation of epothilone in a heterologous host has become a hot spot in the current research. This review summarizes the recent advances in research on the expression of epothilones in hosts such as S. coelicolor, E. coli and M. xanthus as well as the opportunities and challenges they face .