论文部分内容阅读
4名性腺功能低下性阳萎用睾酮的经皮治疗薄膜(TTS-T,ALZA公司产)每天粘贴于阴囊皮肤22小时,共12周,其中2名用了26周。此40Cm~2薄膜每天释放剂量为2.8±0.16mg(均值2.4mg),60Cm~2薄膜释放3.99±0.24mg(均值3.6mg),两种均能迅速增加血清睾酮及双氢睾酮至生理水平,恢复正常勃起活动伴射精频率增加及情绪和精力均增加。对血清性结合球蛋白及雌二醇,前列腺和乳房大小,血液学及肝功能测定,尿流及频率均无改变,对血清胆固醇或低密度脂蛋白无明显改变,高密度脂蛋白有轻度降低倾向,用后无皮肤病发生。
Four hypogonadal impotence transdermal therapeutic films (TTS-T, manufactured by ALZA) with testosterone were applied daily to the scrotal skin for 22 hours for a total of 12 weeks, two of which took 26 weeks. The release of 40Cm ~ 2 film per day was 2.8 ± 0.16mg (average 2.4mg) and 60Cm ~ 2 film was 3.99 ± 0.24mg (average 3.6mg), both of which rapidly increased serum testosterone and dihydrotestosterone to physiological levels, Erectile recovery normal ejaculation frequency and emotional and emotional increased. Serum binding globulin and estradiol, prostate and breast size, hematology and liver function tests, urinary flow and frequency were unchanged, no significant changes in serum cholesterol or LDL, high density lipoprotein with mild Reduce the tendency, no skin disease after use.