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目的探讨短期胰岛素泵强化治疗(CSII)和传统胰岛素两次皮下注射(TDI)对初发2型糖尿病患者治疗效果。方法将63例初发2型糖尿病患者随机分成CSII组和TDⅠ组,以末梢血空腹﹤7.0mmol/L,餐后2h﹤10.0mmol/L为控制目标。观察血糖达标时间、每日胰岛素用量、低血糖发生次数及治疗前后血糖、C肽、糖化血红蛋白、血脂、体质指数变化。结果 CSⅡ组血糖达标的时间短、胰岛素用量少(P<0.05),低血糖发生次数无统计学差异。治疗前后对比,CSⅡ组血糖明显下降,胆固醇、甘油三酯略有下降,体质指数不增加。CSⅡ组,C-肽明显增加,TDⅠ组增加不明显。结论 CSII治疗效果明显优于TDI。
Objective To investigate the therapeutic effect of short-term insulin pump intensive treatment (CSII) and conventional insulin subcutaneous injection (TDI) on newly diagnosed type 2 diabetic patients. Methods Sixty-three patients with newly diagnosed type 2 diabetes were randomly divided into CSII group and TDI group, with fasting blood <7.0mmol / L and postprandial 2h <10.0mmol / L as control targets. Observe the blood glucose compliance time, daily insulin dosage, the number of hypoglycemia and before and after treatment, blood glucose, C-peptide, glycosylated hemoglobin, blood lipids, body mass index changes. Results The blood glucose level of CS Ⅱ group was shortened, the dosage of insulin was less (P <0.05), and the incidence of hypoglycemia was not statistically different. Before and after treatment, blood glucose was significantly decreased in CS Ⅱ group, cholesterol, triglyceride decreased slightly, body mass index did not increase. CS Ⅱ group, C-peptide was significantly increased, TD Ⅰ group did not increase significantly. Conclusion CSII treatment is better than TDI.