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TRH0.22~2mg·kg-1iv使创伤性休克兔血压迅速回升,持续20min基本稳定不变。首次ivTRH和以0.67mg·kg-1·h-1连续静脉输入使休克兔血压在5h内维持在较高水平,同时提高5h存活率。TRH亦能对抗休克时的心率减慢及脉压缩小。但快速ivTRH明显加速休克兔的死亡。
TRH0.22 ~ 2mg · kg-1iv in traumatic shock rabbits blood pressure rose rapidly for 20min basically stable. The first ivTRH and continuous intravenous infusion of 0.67 mg · kg-1 · h-1 kept the blood pressure of shocked rabbits to a higher level within 5h while increasing the survival rate of 5h. TRH can also counter heart rate depression and pulse compression during shock. However, rapid ivTRH significantly accelerated the death of shock rabbits.