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目的:调查北京地区健康成人及儿童未成熟血小板比率(IPF)的参考区间,为该指标应用于临床提供前期研究基础。方法:用全自动血细胞分析仪Sysmex XN-9000对1008份成人EDTA抗凝全血和384份儿童末梢血进行IPF测定。本研究参考个体的筛选及数据分析均参照WS/T 405-2012文件及CLSI推荐的标准进行。经检验结果初筛和体检报告查阅,筛选出参考个体,进行数据统计。分析IPF的分布特点,比较IPF在不同性别及年龄段人群的差异,并计算参考区间。结果:最终745例成人及357名儿童被选为参考个体,以非参数统计方法计算得出成人总体IPF中位数为3.0%,参考区间为1.1%~8.27%,不同性别及年龄组成人的IPF没有明显差异;儿童末梢血IPF的中位数为0.65%,参考区间为0.3%~2.26%,性别间没有明显差异。结论:本研究中儿童末梢血IPF的中位数及参考区间上下限明显低于成人。
Objective: To investigate the reference interval of immature platelet ratio (IPF) in healthy adults and children in Beijing, and to provide the basis of previous research for clinical application of this index in clinical practice. METHODS: IPF was measured in 1008 adult anticoagulated whole blood EDTA and 384 pediatric peripheral blood using a fully automatic hematology analyzer, Sysmex XN-9000. The screening and data analysis of reference individuals in this study were conducted according to the WS / T 405-2012 document and the CLSI recommended standard. The test results of screening and physical examination report access, screening out reference individuals, data statistics. Analysis of the distribution of IPF, IPF in different gender and age groups were compared, and calculate the reference interval. Results: The final 745 adults and 357 children were selected as reference individuals. The non-parametric statistical method was used to calculate the median overall IPF of adults was 3.0% and the reference interval was 1.1% -8.27%. Adults with different genders and age groups There was no significant difference in IPF. The median IPF in peripheral blood of children was 0.65% and the reference interval was 0.3% -2.66%. There was no significant difference between the sexes. Conclusion: The median and reference upper and lower limits of IPF in peripheral blood of children in this study were significantly lower than those in adults.