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目的探讨丝裂霉素（ＭＭＣ）＋异搏定膀胱内灌注预防膀胱移行上皮癌术后复发的效果。方法选取同期住院行膀胱部分切除术的膀胱移行细胞癌患者，分别给予ＭＭＣ＋异搏定、单用ＭＭＣ膀胱腔内灌注治疗，观察两组膀胱癌的复发率及毒副反应。结果ＭＭＣ＋异搏定组治疗后１年、１～３年、３～５年膀胱癌复发率及总复发率均低于单用ＭＭＣ组，Ｐ＜０．０５。两组毒副反应发生率差异无显著性。结论ＭＭＣ＋异搏定膀胱腔内灌注防治膀胱移行上皮癌术后复发优于单用ＭＭＣ灌注治疗，而毒副反应无差别。
Objective To investigate the effect of intravesical instillation of mitomycin C (MMC) + verapamil on the recurrence of bladder transitional epithelial cancer. Methods Patients with bladder transitional cell carcinoma undergoing partial partial cystectomy with MMC were treated with MMC plus verapamil alone and intravesical instillation of MMC intravesically. The recurrence rate and toxicity of bladder cancer in both groups were observed. Results The recurrence rate and recurrence rate of bladder cancer at 1 year, 1 ~ 3 years and 3 ~ 5 years after MMC + verapamil group were both lower than that of MMC group (P <0.05). There was no significant difference in the incidence of side effects between the two groups. Conclusion Intravesical instillation of MMC plus verapamil is better than MMC alone in preventing postoperative recurrence of bladder transitional cell carcinoma without any side effects.