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作者观察了链脲佐菌素(STZ)糖尿病大鼠肝细胞膜胰岛素受体的改变及胰岛素治疗对受体的影响。结果表明:STZ糖尿病大鼠肝细胞胰岛素受体数目及亲和常数均增高,胰岛素治疗可使其逆转。血胰岛素水平与受体数目呈负相关。胰岛素受体的变化与糖尿病病程无关。
The authors observed changes in hepatic cell membrane insulin receptor in streptozotocin (STZ) diabetic rats and the effect of insulin therapy on the receptor. The results showed that: the number and affinity constants of hepatocytes in STZ diabetic rats were increased, insulin therapy can make it reverse. Blood insulin levels and the number of receptors was negatively correlated. Insulin receptor changes have nothing to do with the course of diabetes.