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O-(β-羟乙基)芦丁(维脑路通)用于治疗慢性静脉功能不全已有多年,然而近来有人指出静脉注射大剂量维脑路通治疗动脉硬化所致下肢局部缺血有效,可能由于已报道的它减少红细胞聚集、红细胞乳酸中毒性僵直以及低剪切速率时的表观粘度的作用。为了进一步研究这一问题,瑞典Kristianstad中心医院已对下肢动脉功能不全并且手臂与大趾间的血压差超过50mmHg的患者进行了观察。首先确定,5名患者静脉滴注生理盐水15分钟,对血压差并无影响。
However, it has recently been suggested that intravenous administration of large doses of Venoruton in the treatment of arteriosclerosis-induced ischemia in the lower extremities is effective , Probably due to its reported effect of reducing erythrocyte aggregation, erythrocyte lactic acidosis, and apparent viscosity at low shear rates. To further investigate this issue, Kristianstad Central Hospital in Sweden has observed patients with lower extremity arterial insufficiency and a blood pressure difference of more than 50 mmHg between the arm and the big toe. First determine that five patients intravenous infusion of saline for 15 minutes, no effect on blood pressure.