本文报道了用溶剂过滤法改善电子密度图,依据Collins提出的一级结构,重新建立天花粉蛋白分子模型。使用2.6分辨率衍射强度数据和约束参数最小二乘法,对处于晶体学不对称单元中两个天花粉蛋白分子(共3828个非氢原子)进行晶体学修正。修正结果,偏离因子R=0.223,键长根均方误差r.m.s=0.023,新的分子模型和以2F_0-F_o为系数的电子密度图符合甚好。 This paper reports the improvement of the electron density map by solvent filtration and the re-establishment of the trichosanthin molecular model based on the primary structure proposed by Collins. Crystallographic modifications were performed on two trichosanthin molecules (3828 non-hydrogen atoms) in the asymmetric unit of crystallography using 2.6-resolution diffraction intensity data and constrained parameter least squares. The results of the correction, the deviation factor R = 0.223, root mean square error of key length r.m.s = 0.023, the new molecular model and 2F_0-F_o as the coefficient of electron density map in good agreement.